Leflunomide is a medication primarily used to treat certain autoimmune conditions, such as rheumatoid arthritis and psoriatic arthritis. Proper administration of this medication is crucial for its effectiveness and to minimize potential side effects. This article outlines essential guidelines on how to take leflunomide safely and effectively.
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1. Dosage and Administration
When taking leflunomide, it’s important to follow your healthcare provider’s instructions regarding dosage. The standard initial dosage is often 100 mg once daily for the first three days, followed by a maintenance dose of 20 mg once daily. However, your healthcare provider might adjust this based on your specific condition and response to treatment.
2. Taking Leflunomide
Leflunomide can be taken with or without food. However, consistency is key; try to take it at the same time each day to maintain stable levels in your bloodstream. Here are some additional tips for taking leflunomide:
- Always swallow the tablets whole with a glass of water.
- Do not crush, chew, or dissolve the tablets.
- If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and resume your regular schedule. Never take a double dose.
- Discuss any concerns about missed doses with your healthcare provider.
3. Monitoring and Follow-Up
Regular monitoring is essential while on leflunomide. Your healthcare provider will likely perform blood tests to monitor liver function and your white blood cell count, as the medication can affect these parameters. Schedule follow-up appointments as recommended, and immediately report any unusual symptoms or side effects to your healthcare provider.
4. Possible Side Effects
While many people tolerate leflunomide well, some may experience side effects. Common side effects include:
- Nausea
- Diarrehea
- Headaches
- Skin rash
If you experience severe side effects or symptoms like liver problems (e.g., jaundice), severe abdominal pain, or signs of infection, seek medical attention promptly.
5. Special Considerations
It’s crucial to consider the following when taking leflunomide:
- Women who are pregnant or planning to become pregnant should inform their doctor immediately, as leflunomide can cause harm to the fetus.
- Inform your healthcare provider about any other medications you are taking, as drug interactions can occur.
- Avoid alcohol consumption while on this medication, as it can increase the risk of liver damage.
By following these guidelines, you can help ensure that you take leflunomide safely and effectively. Always consult your healthcare provider for personalized advice, adjustments, or concerns regarding your treatment.

